Comparison of intra-articular injection of hydrolyzed type 1 collagen, platelet-rich plasma and hyaluronic acid on pain, stiffness and performance of patients with knee osteoarthritis

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年3月6日

适应症

试验速览

暂无简介。

•People aged 40 to 70 years who are diagnosed with knee osteoarthritis based on history and physical examination.
•Duration of symptoms is more than 3 months.
•Confirmation of diagnosis using knee x-ray (Kellgren-Lawrence grade 2-3)
•The patient's BMI should be between 18 and 30.
•Willingness of the patient to participate in the study

•History of immunodeficiency and collagen disorders and uncontrolled diabetes
•History or presence of malignant disorders, infection or active wound in the knee area
•Recent history of severe knee injury
•Autoimmune and platelet disorders
•Treatment with anticoagulant and antiplatelet drugs within 10 days before injection
•Use of NSAIDs within 2 days before injection
•History of intramuscular injection or oral use of systemic corticosteroids 2 weeks before injection
•History of any intra-articular injection of the knee during the last 6 months
•Hemoglobin less than 11 g/dL
•Platelet count less than 150,000/ml
•History of vasovagal shock
•Pregnancy or breastfeeding
•Geneva valgum/varum more than 20 degrees
•Hypersensitivity to hyaluronate
•Allergy to bovine proteins, poultry products, eggs and collagen
•Hemarthrosis, erythema and psoriatic lesions
•Clinical or para-clinical symptoms in favor of spinal canal narrowing, neuropathy or active lumbar radiculopathy

发起方