Oxytocin Effect on Attentional Bias Towards Emotional Expression Faces in Individuals With High and Low Autistic Traits: A Functional Magnetic Resonance Imaging (fMRI) Study
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- attentional bias toward emotional expression faces
研究概览
简要总结
to investigate whether oxytocin alter attentional bias towards emotional expression faces in individuals with high and low autistic traits, and the brain mechanism of this effect
详细描述
In the present study, investigator plan to use a double-blind, between-subject placebo controlled design.Firstly, all healthy male subjects' autistic trait levels will be assessed by the Autism Spectrum Quotient (ASQ) and only subjects with higher or lower ASQ score will be recruited in the next experiment and divided into high and low subgroup. Then, subjects are randomly assigned to receive either intranasal administration of oxytocin (24 IU) or placebo. 45 min later, subject need to complete an attentional bias task named rapid serial visual presentation (RSVP) task in fMRI scanner.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
研究组 & 干预措施
high autistic and oxytocin group
subject with high ASQ scores will receive oxytocin treatment
干预措施: screen high autistic subjects (Behavioral)
high autistic and oxytocin group
subject with high ASQ scores will receive oxytocin treatment
干预措施: oxytocin (Drug)
low autistic and oxytocin group
subject with low ASQ scores will receive oxytocin treatment
干预措施: screen low autistic subjects (Behavioral)
low autistic and oxytocin group
subject with low ASQ scores will receive oxytocin treatment
干预措施: oxytocin (Drug)
high autistic and placebo group
subject with high ASQ scores will receive placebo treatment
干预措施: screen high autistic subjects (Behavioral)
high autistic and placebo group
subject with high ASQ scores will receive placebo treatment
干预措施: placebo (Drug)
low autistic and placebo group
subject with low ASQ scores will receive placebo treatment
干预措施: screen low autistic subjects (Behavioral)
low autistic and placebo group
subject with low ASQ scores will receive placebo treatment
干预措施: placebo (Drug)
结局指标
主要结局
attentional bias toward emotional expression faces
时间窗: 1 hour
attentional bias was measured by the accuracy of each emotional faces in the RSVP task
次要结局
- brain activity during RSVP task(1 hour)
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China