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临床试验/NCT02639897
NCT02639897尚未招募不适用

Evaluation of Functional Dimensions of Macintosh Blade During Laryngoscopy in Patients With Normal Mouth Opening: Development of a Feasibility Model for Facilitation of Laryngoscopy in Cases of Mouth Opening Restriction Due to Submucous Fibrosis

Sir Ganga Ram Hospital2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2026年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
100
试验地点
2
主要终点
Macintosh Blade Length Measurement (in centimeters)

研究概览

简要总结

Direct laryngoscopy and intubation is an essential initial aspect of airway access during general anesthesia. To perform the procedure effectively, it requires adequate mouth opening, head and neck movement, and a normal temporo-mandibular joint mobility. Any issue with the above three results in a compromised upper airway at the outset and the condition is known as anticipated difficult airway, i.e. an airway that is difficult to access with conventional laryngoscopy and intubation methods. To overcome the difficulty, either one has to resort to newer advanced technique and equipment or the available conventional technique needs to be refined and modified to suit the requirement. While the former requires extraordinary expertise and finances, an option difficult to achieve in developing countries; the latter warrants focused interest to develop alternative approach with the same set of equipments.

Since submucous fibrosis and the associated restricted mouth opening have taken the proposition of an epidemic owing to widespread use of betel nut and tobacco; these patients, when requiring surgery, are difficult candidates for GA and airway control. The fact that, when they arrive as pre-surgical candidates, they have variable degree of mouth opening restriction, which if approached with a strategy, may be amenable to conventional control of airway. If investigators paint all the patients with mouth restriction as difficult airway, it will result in uncalled surgical, economic, health system and psychological burden. Therefore, it is prudent to undertake research relating to refinement of airway access techniques with the easily available, cheap and user- friendly equipment (conventional laryngoscope), such that a proportion of above stated burden can be reduced.

In view of the above, investigators plan to undertake a study to enhance our working knowledge with a conventional laryngoscope (Macintosh) to facilitate ways to control the airway difficulty secondary to mouth opening restriction. Investigators believe that the prospective knowledge thus generated would help us identify whether there is a feasibility of conventional airway management or an alternative advanced access technique is needed in the first place. This will prevent undue cancellations, delayed surgeries, and patient morbidity.

详细描述

Upper airway access is one of the essential components of general anaesthesia, and more often than not, it is gained by direct laryngoscopy followed by tracheal intubation. While direct laryngoscopy depends on laryngoscope blade design and the anesthetists' skill set, the ease of tracheal intubation is influenced by the line-of-view to the glottis gained by the laryngoscopy maneuver. In patients with normal mouth opening (≥4.0 cm), the act of conventional airway access is not difficult given that the neck extension and the TMJ joint mobility is within normal limits. Conversely, it becomes difficult in patients who have mouth opening restriction, and hence they are adjudicated as 'anticipated difficult airway' (ADA). The ADA, attracts several issues that, not uncommonly, converges on to time inefficiency, heightened equipment cost, operator anxiety, and unfortunately, patient morbidity. There are many causes of restricted mouth opening, defined technically as reduced inter-incisor distance (IID) including trauma, TMJ movement limitation, intra/extra-oral pathology resulting in pain, or the most common pathology in the Indian subcontinent, oral submucosal fibrosis (SMF). While the pathology itself is a forerunner of oral mitosis, it is the associated restricted mouth opening component that put conventional airway access efforts of the anaesthesiologist in spot, and consequently, a whole, sometimes unnecessary rigmarole has to be activated under the heading of 'advanced approach to ADA'.

Oral submucous fibrosis (SMF) is a well-recognized, potentially malignant progressive condition afflicting the oral cavity that is characterised by a reduced mouth opening. The reduction in mouth opening occurs due a vertical reorientation of collagen fibrils that are normally haphazardly arranged. Of the currently available multiple classifications to identify disease stage/severity, the functional classification based on the inter-incisor distance (IID) seems to be most relevant.

IID forms an important component of airway examination and a value of less than 3-cm is suggestive of difficulty in airway management. However, despite the above, SMF is largely unrecognized as a cause of airway difficulty, and even when recognized, no set protocol is available to ensure (as far as possible) a favourable outcome in terms of least morbidity to the patient, and stress to the anaesthesiology team in question.

Need Assessment for the Study Generally, in a tertiary level centre, with all facilities at hand, cases with a reduced IID are normally tackled using a fiberoptic bronchoscope guided tracheal intubation. However, in India, the burden of this disease lies to a great extent in rural/suburban settings where access to a fiberoptic bronchoscope is unlikely. As a result these cases are referred to 'higher' centres for management. This imposes undue burden (logistics/ financial) onto patients and their families. Hence, there is a great need for anaesthesiologists working at the primary/secondary level healthcare set up to get oriented to this problem and be able to manage it with conventional options (direct laryngoscopy & intubation) available to them.

Scientific Contention Direct laryngoscopy remains the foremost among the various techniques available to access the upper airway and the Macintosh blade has been the most preferred blade type. In order to improve direct laryngoscopy, many modifications of blade design have been tested/ compared with the Macintosh blade, but apparently, the clarity as to which laryngoscope blade is most suited for a given airway remains low. For the majority of practicing anaesthesiologists, the availability of different laryngoscope designs has only increased the hit-and-trial option for laryngoscopy.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Consenting adults
  • Both gender
  • Age: 20-65 years
  • Normal preoperative upper airway evaluation and without the presence of anticipated airway access difficulty
  • Patients scheduled for surgery under general anaesthesia with airway control by direct laryngoscopy and tracheal intubation

排除标准

  • Patient refusal
  • Anticipated airway access difficulty
  • Edentulous patients
  • Patients with dental problem (missing tooth, overlap, cosmetic treatment)
  • Vulnerable Patients: High risk situation, major surgery, extremes of age, obstetric patients
  • Previously difficult airway

结局指标

主要结局

Macintosh Blade Length Measurement (in centimeters)

时间窗: 0 to 5-minutes

Length of Macintosh blade size 3 and 4 as such (static) and during active direct laryngoscopy (active).

Macintosh Blade Width Measurement (in centimeters)

时间窗: 0 to 5-minutes

Width of Macintosh blade size 3 and 4 as such (static) and during active direct laryngoscopy (active).

Inter-incisor Angle on Macintosh Blade Contact Point (in degrees)

时间窗: 0 to 5-minutes

The angle formed by the line between the two contact points, viz. a point formed by upper incisor contact of upper flange curve (convex) of the Macintosh laryngoscope blade, and a point of contact between the lower incisor contact with lower flange curve (concave curve) of the Macintosh laryngoscope blade. The line formed by joining these two contact points with the baseline of the laryngoscope will form an angle. This angle will be noted as functional separation of eugnathic, retrognathic or prognathic maxilo-mandibular orientation

次要结局

  • Upper Airway Measurements (in centimeters)(0 to 5-minutes)
  • Correlation Assessment(0 to 5-minutes)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nitin Sethi, DNB

Consultant

Sir Ganga Ram Hospital

研究点 (2)

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