Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Dichlorofluorescein fluorescence slope
研究概览
简要总结
In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week low-fat/low-cholesterol (LFLC) normocaloric diet.
详细描述
HDL particles can change their composition and function in response to a variety of pathological conditions and environmental stimuli. It has been previously shown that a western diet is able to drastically modify biochemical composition, anti-inflammatory and anti-oxidant properties of HDL in animals. In humans little is known on the role of diet on HDL function and composition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects ≥ 18 and ≤40 years of age
- •Lean or overweight (BMI: 18 to 29,9 kg/m2)
- •Normal liver and kidney function
- •Normal thyroid function
- •Stable weight in the last 3 months
- •Read and understood the informed consent form and signed it voluntarily
排除标准
- •Liver, heart, kidney, lung, infectious, neurological, psychiatric, endocrine, immunological or neoplastic diseases
- •Chronic use of drugs or vitamin supplements
- •Pregnancy or lactation
结局指标
主要结局
Dichlorofluorescein fluorescence slope
时间窗: 14 days
次要结局
- hydroxyeicosatetraenoic acid(14 days)
- hydroxyoctadecadienoic acid(14 days)
研究者
Andrea Natali
Professor Andrea Natali
Azienda Ospedaliero, Universitaria Pisana