Stockholm Prospective Acute Kidney Injury Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,861
- 试验地点
- 2
- 主要终点
- In-hospital outcome
研究概览
简要总结
Since 2009, adult patients with acute kindney injury (AKI) at the department of Nephrology, Danderyd University Hospital and Karolinska Institutet, have been included in a prospective cohort. All patients were treated and evaluated according to a detailed clinical memorandum, and data collected prospectively.
By 2020, 1861 patiens have been included of which 1519 fulfill current AKI criteria (as defined by KDIGO AKI guidelines) and will be evaluated regarding the following main research questions:
- Descriptive study on patient characteristics, changes in biomarkers and in-hospital outcome.
- One year outcome with focus on renal and cardiovascular outcomes.
- Long-term outcome (up to 10 years) with focus on renal and cardiovascular outcomes.
详细描述
Acure kidney injury (AKI) remains a complex clinical challenge associated with high risk for short-term and long-term adverse events. Since 2009 patients with AKI at the department of Nephrology, Danderyd University Hospital and Karolinska Institutet, have been included in a prospective cohort. Adult patients with either s-creatinine >130 micromol/L and previously unknown level, or 30% increase from previous known level were included; patients on dialysis were not included. All patients were treated and evaluated according to a detailed clinical memorandum, and data collected prospectively.
By 2020, 1861 patiens have been included of which 1519 fulfill current AKI criteria and will be evaluated regarding the following main research questions:
- Descriptive study on in-hospital outcome (death, renal recovery), patient characteristics, hyperkalemia and changes in biomarkers reflecting inflammation, acidosis and malnutrition.
- One year outcome with focus on renal and cardiovascular outcomes (death, new dialysis, worsened renal function, myocardial infarction, stroke, or heart failure; MARCE).
- Long-term outcome (up to 10 years) with focus on renal and cardiovascular outcomes (MARCE).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Ongoing dialysis treatment.
结局指标
主要结局
In-hospital outcome
时间窗: From admission until discharge or death, assessed for a period of up to 3 months
Death
Long-term outcome
时间窗: From admission until 10 years
Descriptive study on Major Adverse Renal or Cardiovascular Events (MARCE)
1-year outcome
时间窗: From admission until 1 year
Descriptive study on Major Adverse Renal or Cardiovascular Events (death, new dialysis, worsened renal function, myocardial infarction, stroke, or heart failure; MARCE)
次要结局
- In-hospital biomarkers(From previous values or values at admission until discharge or death, assessed for a period of up to 3 months)
- In-hospital partial renal recovery(From admission until discharge or death, assessed for a period of up to 3 months)
- In-hospital renal recovery(From admission until discharge or death, assessed for a period of up to 3 months)
研究者
Jonas Spaak
Associate professor
Danderyd Hospital