The Use of Fermented Whey Concentrate in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Change in microbiota activity
研究概览
简要总结
Pilot trial: 6-week single arm intervention. Healthy adults (male and female) consume Molkosan (fermented whey) twice a day (AM & PM).
详细描述
Molkosan® is made from fresh organic whey using a special fermentation process involving lactic acid producing bacteria (L+ lactic acid 70g/L). The company, A.Vogel (Roggwil, Switzerland) will provide the product and we will collect biological samples for analysis in a proof of concept study design that will provide preliminary data for future larger studies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Unlabelled bottles of treatment
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18-65
- •BMI 18-40 kg/m-2
排除标准
- •Severe gastrointestinal disorders,
- •Kidney disease,
- •Thromboembolic or coagulation disease,
- •Hepatic disease,
- •Alcohol or any other substance abuse
- •Eating disorders
- •Unregulated thyroid disease
- •Dairy intolerance
- •Antibiotic use within the last 3 months, including prescribed use
- •Current prebiotic or prebiotic use
研究组 & 干预措施
Molkosan
Consumption of Molkosan (fermented whey) 20ml to be diluted in 200ml water prior to use twice a day (morning & evening).
Total duration was 6 weeks.
干预措施: Molkosan (Dietary Supplement)
结局指标
主要结局
Change in microbiota activity
时间窗: Baseline, day 21 and 42
Faecal short-chain fatty acids, measured by gas chromatography
次要结局
- Change in glucose tolerance (Oral glucose tolerance test (OGTT)(Baseline, day 21 and 42)