The Effect of Midazolam on Fluid Responsiveness in Septic Patients
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- percentage of participants with more than 10% increase of cardiac index by passive leg raising after sedation
研究概览
简要总结
Fluid resuscitation remains the foundation for septic treatment.The evaluation of fluid responsiveness has significance in volume resuscitation for septic shock patients. As the sedative which is commonly used in ICU, Midazolam is supposed to change fluid responsiveness for the pharmacological effect of venodilation. However, the hypothesis has not been certified clinically. In this research, the investigators aim to test the hypothesis that Midazolam can increase fluid responsiveness(using passive leg raising test) in septic shock patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Midazolam
Midazolam infused at a 0.03mg/kg loading dose ,and 0.02-0.1mg/kg.h maintenance dose to achieve Ramsay score of 4
干预措施: sedatives(Midazolam and Propofol) (Drug)
Propofol
Propofol infuse at a loading dose of 0.5mg/kg，and 0.5-2.0mg/kg.h maintenance dose to achieve Ramsay score of 4
干预措施: sedatives(Midazolam and Propofol) (Drug)
结局指标
主要结局
percentage of participants with more than 10% increase of cardiac index by passive leg raising after sedation
时间窗: Baseline,after sedation
次要结局
未报告次要终点
研究者
Jianfeng Xie
Department of critical care medicine, Zhongda Hospital
Southeast University, China