Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Multi-organ failure
研究概览
简要总结
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.
The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
详细描述
The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.
Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with severe sepsis or septic shock on mechanical ventilation
- •Enrolled in the initial six hours of ICU admission
排除标准
- •Patients with withdrawal or hospice order.
- •Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
- •Patients with COPD.
- •Patients transferred from outside ICU with ongoing sepsis management for more than six hours.
结局指标
主要结局
Multi-organ failure
时间窗: daily for 48 hours then weekly for 2 weeks.
Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.
次要结局
- Mortality(ICU mortality)
研究者
Rosa Estrada Y Martin
Associate Professor - IM, Critical Care
The University of Texas Health Science Center, Houston