NCT00953368Unknown1 期
Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
适应症
干预措施
试验速览
- 阶段
- 1 期
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- cognitive function
研究概览
简要总结
The aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective off-pump coronary artery bypass graft surgery
排除标准
- •Emergency operation
- •Preoperative use of inotropic drugs or mechanical assistant device
- •Ejection fraction less than 30%
- •Combined operation using CPB such as valve surgery
- •Previous psychiatric and neurologic disorder
- •Inability to perform the cognitive function test
研究组 & 干预措施
Remote ischemic preconditioning
Active Comparator
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
干预措施: remote ischemic preconditioning (Procedure)
control
Placebo Comparator
sham placement of a blood-pressure cuff around the upper limb without inflation
干预措施: remote ischemic preconditioning (Procedure)
结局指标
主要结局
cognitive function
时间窗: preoperative, 1 week and 6 months after surgery
次要结局
未报告次要终点
研究者
研究点 (1)
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