NCT05362565Unknown不适用
Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity
University Hospital, Bordeaux1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2022年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Positivity rate of patients for whom a diagnosis of monogenic obesity will be obtained when all analyses have been performed.
研究概览
简要总结
Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Recruitment age: 2-17 years
- •Body mass index, greater than the International Obesity Task Force (IOTF) 30 curve before the age of 5
- •Care at the specialized pediatric obesity center (CSO) of the Bordeaux University Hospital
- •Informed consent signed
排除标准
- •no informed consent
结局指标
主要结局
Positivity rate of patients for whom a diagnosis of monogenic obesity will be obtained when all analyses have been performed.
时间窗: Inclusion visit
次要结局
- Number of patients for whom a genetic finding will have changed management and description of changes.(Inclusion visit)
- Number of Patients eligible for a drug targeting single-gene obesity(Inclusion visit)
研究者
研究点 (1)
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