Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus and the Effect of Dexmedetomidine on the Stress Response in Patients With Diabetic Undergoing Gastric-bypass Surgery
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Stress Indicators
研究概览
简要总结
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and intravenous anesthesia on stress reactions generated by patients with diabetes conducted gastric - bypass surgery , and choose a best way from three kinds of anesthesia to control stress reaction of diabetics. After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.
详细描述
Research content and indicators
- Preparation of serum: 3ml of blood were taken before induction of anesthesia (after entering the operating room), surgery began 1h, surgery began 2h, 24h after surgery, and placed at dry tube, centrifuged for 10min at 3000g after placing at room temperature for 2h , the resulting supernatant was subpassaged in tube, stored at -20℃ until analysis.
- Indicators to detect in serum contained Tumor Necrosis Factor-α, Interleukin-6, Interleukin-10, plasma glucose, cortisol,insulin and c-peptide.
- Record the vital signs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists（ASA）Ⅰ ~ Ⅱpatients
- •Type 2 Diabetes Mellitus patient undergoing Laparoscopic Gastric Bypass surgery
- •between 18 and 60 years of age
排除标准
- •A history of cardiopulmonary disease, liver and kidney dysfunction, abnormal coagulation
- •Thyroid disease
研究组 & 干预措施
Intravenous anesthesia
We use total intravenous anesthesia to assess the stress response.
干预措施: different types of anesthesia (Other)
Intravenous and Inhalation anesthesia
We use intravenous and inhalation anesthesia during the surgery.
干预措施: different types of anesthesia (Other)
Inhalation anesthesia
We use inhalation anesthesia during the surgery.
干预措施: different types of anesthesia (Other)
Dexmedetomidine
the effect of dexmedetomidine on the stress responses generated by patients with diabetic given gastric-bypass surgery : Group A group given the best anesthetic technique from preliminary work + dexmedetomidine Dexmedetomidine as a inducer was given intravenous infusion loading dose 1.0μg/kg for 10min, maintained intravenous infusion by 0.4μg/kg/h.
Group B group given the best anesthesia method from preliminary work(not using dexmedetomidine).
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Stress Indicators
时间窗: 72 hours
We use different anesthesia method to assess the stress indicators,aiming to choose an apposite anesthesia to reduce stress response in laparoscopic gastric bypass for type 2 diabetes mellitus.The stress indicators include Tumor Necrosis Factor-α,Interleukin-10,Interleukin-6,C-peptide,Cortisol,Insulin and Adrenocorticotropic hormone.
次要结局
- Vital Signs(during surgery)
研究者
Wenbin Qie
Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
Guangzhou General Hospital of Guangzhou Military Command