The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Activity-based protein profiling (ABPP) will be used to assess the enzymes involved in calcium induced stress signals and endocannabinoid activation
研究概览
简要总结
Despite the strong association of hyperparathyroidism with arachidonic acid related lipid signals, little research has been performed over the years. A better understanding of the link between arachidonic acid remodeling, prostaglandin and endocannabinoid production with primary hyperparathyroidism in primary tissue/cells might open up new avenues for biomarker and thus to a potential therapeutic target.
Arachidonic acid remodeling might also have an impact on depression and elevated cytokines in patients with primary hyperparathyroidism. The investigators therefore will assess the correlation between postoperative improvement of PHQ-9 and cytokine levels with arachidonic acid remodeling.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Primary hyperparathyroidism with planned surgery
- •Written informed consent
排除标准
- •Age <18 years
- •Secondary/tertiary hyperparathyroidism
- •Renal insufficiency
- •Participant is pregnant
- •Participant is incapable of giving an informed consent
结局指标
主要结局
Activity-based protein profiling (ABPP) will be used to assess the enzymes involved in calcium induced stress signals and endocannabinoid activation
时间窗: 2 months
次要结局
- Measurement of the level of parathyroid hormone(2 months)
- Measurement of the level of calcium(2 months)
- Measurement of the level of cortisol(2 months)
- Measurement of the level of 25-hydroxyvitamin D(2 months)
- Measurement of the levels of the enzymes involved in the endocannabinoid system activation (diacylglycerol lipase; monoacylglycerol lipase, phospholipases, cyclooxygenases)(2 months)
- Measurement of the level of endocannabinoids, arachidonic acid species, prostanoids and related anti-inflammatory lipids(2 months)
- Measurement of the level of IL-6 and TNF-α(2 months)
- Assessment of Patient Health Questionnaire - 9(2 months)