Early Detection of Diastolic Dysfunction and the Role of Lifestyle Measures in Its Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Exercise echo Doppler will be done at baseline and after completion of 6 months of an exercise program
研究概览
简要总结
The project aims to investigate the effect of a regular exercise for 6 months on diastolic parameters in patients who present with shortness of breath and who have evidence of early diastolic dysfunction on echocardiography. Patients will be enrolled from the VA General Medicine and Cardiology Clinics, and will be screened for diastolic dysfunction. Once enrolled, they will be on an exercise regimen that involves aerobic exercise for 30-45 minutes five times a week at home. The participants will have an initial supervised exercise session with the VA Cardiac Rehabilitation team, and will have either every other week or monthly supervised sessions at the VA Cardiac Rehabilitation Center to monitor their progress. Clinical, biometric, laboratory and echocardiographic parameters will be obtained before and after the 6 month period.
详细描述
Introduction:
Diastolic dysfunction (DD) accounts for >50% of all heart failure (DHF) hospitalizations and this number is increasing with age, obesity and diabetes.
There are no proven treatments for DHF apart from blood pressure control.
Aim:
If diagnosed early, is this reversible with lifestyle changes; namely, aerobic exercise and weight reduction?
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with dyspnea/shortness of breath
- •Age 40-65 years of age
- •Sedentary lifestyle (<150 minutes of exercise/week)
- •Echocardiographic evidence of early diastolic dysfunction: mitral E/A <0.9, OR resting E/E' between 8-15 cm/s, OR post-exercise E/E' >13 cm/s.
- •Exclusion criteria:
- •Age <40 years or >65 years
- •Coronary Artery Disease by angiography or evidence of ischemia on a stress test
- •Systolic Dysfunction (LV Ejection fraction <50%)
- •Congestive Heart Failure Functional Class III or IV
- •Moderate to severe COPD (FEV <80% predicted)
- •Moderate to severe valvular heart disease, except tricuspid regurgitation
- •Inability to get heart rate >/= 85% of maximum predicted heart rate
- •Uncontrolled hypertension (systolic BP>140mmHg, diastolic BP>90mmHg) despite medical therapy
- •On echocardiogram, RV systolic pressure >60mmHg that suggests severe pulmonary hypertension
- •On echocardiogram, left atrial size> 6.5 cm or left atrial volume > 35 ml/BSA
排除标准
- 未提供
结局指标
主要结局
Exercise echo Doppler will be done at baseline and after completion of 6 months of an exercise program
时间窗: Beginning of study participation and after 6 months of study participation
次要结局
未报告次要终点
研究者
Anand Chockalingam
Prof Assoc, Medicine-Cardiology
University of Missouri-Columbia