NL-OMON39985招募中不适用
Prospective study on the metabolic and linear growth effects of growh hormone treatment in children with Kabuki Syndrome - Metabolic effects of Growth Hormone
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 20 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 11（—）
入选标准
- •-Children with the KDM6A orKMT2D (MLL2) mutation.;-Children who meet at least four out of five KS characteristics:;#Facial features: long palpebral fissures with eversion of outer third, arched eyebrows with sparse outer half, prominent and/or misshapen ears, and depressed nasal tip.;#Skeletal abnormalities.;#Intellectual disability (mild to moderate).;#Postnatal short stature.;#Abnormalities of dermal ridges.;-Informed consent.;-Age >= four years.
排除标准
- •-Children with a chronological or bone age greater than 8 years for girls and 10 years for boys, because of the influence of puberty.;-Extremely low dietary intake (less than minimal required intake for age according to WHO criteria). ;-Use of medication that might interfere with growth during GH therapy, such as corticosteroids and sex steroids.
研究者
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