NCT03027479已完成不适用
Study of Differences in Skeletal Muscle Energy Metabolism Alterations in Women With Weight Loss and Ovarian and/or Endometrial Cancer Based on the Body Mass Index
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Measurement of muscle mitochondrial bioenergetics according to BMI
研究概览
简要总结
the aim is to study skeletal muscle metabolism alterations métaboliques associated with weight loss in women with ovarian and/or endometrial cancer according to BMI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged 18 years old and more
- •Ovarian and/or endometrial cancer
- •weight loss related to cancer (weight loss > 5% weight in one month or 10% in 6 months)
- •Indication to therapeutic surgery
- •Women affiliated to social security scheme
- •Women who can understand French and able to sign Informed consent
排除标准
- •Unbalanced Diabetes
- •Chronic neuromuscular disorder
- •Any severe uncontrolled medical condition
- •Control group selection criteria:
- •Inclusion Criteria:
- •Women aged 18 years and more
- •Surgery Indication for a benign endometrial and/ or ovarian disease
- •Patient affiliated to social security scheme
- •Women who can understand French and able to sign Informed consent
- •Exclusion Criteria:
- •Unbalanced Diabetes
- •Chronic neuromuscular disorder
- •Any severe uncontrolled medical condition
结局指标
主要结局
Measurement of muscle mitochondrial bioenergetics according to BMI
时间窗: muscle biopsy realized during surgery
Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy
次要结局
- on muscle biopsy(muscle biopsy realized during surgery)
- on ovarian cancer tumor samples(ovarian tumor biopsies realized during surgery)
- on white adipose tissue(adipose tissue samples taken during surgery)
- on computerized tomography(1 day of abdominal CT scan imaging procedure performed at diagnosis)
研究者
研究点 (2)
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