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临床试验/NCT05534841
NCT05534841已完成不适用

Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Centre Hospitalier Universitaire de Nīmes1 个研究点 分布在 1 个国家目标入组 99 人开始时间: 2022年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
99
试验地点
1
主要终点
Complete response MRI criterion

研究概览

简要总结

Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Rectal adenocarcinoma
  • Locally advanced
  • Neoadjuvant therapy
  • MRI restaging
  • Rectal surgery
  • Definitive anatomopathology study

排除标准

  • 未提供

结局指标

主要结局

Complete response MRI criterion

时间窗: Day 0: immediately after the procedure

We selected several objective MRI criterion among literature and compared them between the two groups.

次要结局

  • MRI accuracy(Day 0: immediately after the procedure)

研究者

发起方
Centre Hospitalier Universitaire de Nīmes
申办方类型
Other
责任方
Sponsor

研究点 (1)

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