Facilitating opiate recovery: withdrawal and abstinence through detoxification support

Imperial College London0 个研究点目标入组 112 人开始时间: 2024年1月31日最近更新: 2024年2月19日

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•1. Classified or determined by their addiction service as ready for dose reduction or detox
•2. >18 years old
•3. Current or previous DSM-5 moderate to severe opioid use disorder or ICD10/11 opioid dependence
•4. Currently treated with methadone substitution therapy
•5. The client wishes to undergo methadone detoxification and/or dose reduction

•1. Lack of capacity to consent
•2. Unable to take oral medication
•3. Contraindication for baclofen, as per SmPC guidance
•4. History of allergic or adverse reactions to baclofen, or placebo, or any of their excipients
•5. Where there are Special warnings and precautions for us according to the SmPC AND where the risk vs benefit ratio for prescribing is not in favour of prescribing medication (see SmPC)
•6. Current and ongoing substance dependence (including alcohol), except for opiates and nicotine, with no desire to stop at this time
•7. Clinician does not deem that the individual is suitable to undergo dose reduction or detoxification from methadone at this time
•8. Use of regular prescription or illicit medications or drugs which in the opinion of the investigators will interfere with subject safety or study integrity
•9. Severe chronic obstructive pulmonary disease or Type 2 respiratory failure
•10. Unable to follow the study protocol due to serious mental health disorder e.g. enduring psychotic illness, suicidal intent
•11. Any woman who is pregnant, of child-bearing potential refusing a pregnancy test or unwilling to use adequate contraception for the duration of the trial

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