Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- Neuropsychological measure 5
研究概览
简要总结
Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
详细描述
A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Member of Whitehall II cohort attending at UCL for phase 11
排除标准
- •Not suitable for MRI, travelling to Oxford, seriously physically ill
结局指标
主要结局
Neuropsychological measure 5
时间窗: 2012-2016
CANTAB Simple and Choice Reaction Time (processing speed)
Neuropsychological measure 6
时间窗: 2012-2016
WAIS-R Digit Symbol Test (processing speed)
Neuropsychological measure 1
时间窗: 2012-2016
National Adult Reading Test (premorbid intellectual ability)
Neuropsychological measure 3
时间窗: 2012-2016
Rey Complex Figure copy and delayed recall (visual episodic memory)
Neuropsychological measure 2
时间窗: 2012-2016
Montreal Cognitive Assessment (MoCA)
Neuropsychological measure 8
时间窗: 2012-2016
WAIS-R Digit Span forward and backwards (executive functioning)
MRI Measures 3
时间窗: 2012-2016
Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes
MRI Measures 5
时间窗: 2012-2016
Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC)
Neuropsychological measure 4
时间窗: 2012-2016
Hopkins Verbal Learning Test Revised (verbal episodic memory)
Neuropsychological measure 9
时间窗: 2012-2016
Graded Naming Test (semantic memory)
MRI Measures 1
时间窗: 2012-2016
Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions
MRI Measures 2
时间窗: 2012-2016
Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis
MRI Measures 4
时间窗: 2012-2016
Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS)
Neuropsychological measure 7
时间窗: 2012-2016
Trail Making Test A and B (processing speed/executive functioning)
次要结局
未报告次要终点