IS Three d Power Doppler of the Endometrial and Subendometrial Regions Effective?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 主要终点
- chemical pregnancy
研究概览
简要总结
Three D power Doppler US was done for every woman at the day after HCG administration. Ovum pick up was done after 35 hours following HCG administration. The luteal phase was supported by progesterone 300 mg per day (progest, micronized progesterone 100mg, Technopharma, Egypt, for pharco pharmaceuticals, Amriya- Alexandria). Five days following ovum pick up, the embryos were transferred at the blastocyst stage.
详细描述
All women underwent long agonist protocol for controlled ovarian hyperstimulation described by Chang et al. (14) The GnRH agonist was started in the previous mid-luteal phase (decapeptylR R 0.1mg, Triptorelin-Acetate, Ferring GmbH, Wittland 11, D-24109, and Kiel, Germany). After the confirmation of pituitary down regulation (serum LH less than 5 m IU/ml and serum E2 less than 50 pg /ml), the HMG ampoules were started by 225 IU/day (Gonapure 75 IU, IBSA Institute Biochimique SA, Switzerland). During the follow up of overstimulation, the doses were adjusted according to the response of patient. All women underwent serial TVS until at least three dominant follicles were reached in every woman. When the dominant follicles reached 18-20 mm, HCG 10000 (Choriomon 5000 IU, IBSA Institute Biochimique SA, Switzerland) was administered. Three D power Doppler US was done for every woman at the day after HCG administration. Ovum pick up was done after 35 hours following HCG administration. The luteal phase was supported by progesterone 300 mg per day (progest, micronized progesterone 100mg, Technopharma, Egypt, for pharco pharmaceuticals, Amriya- Alexandria). Five days following ovum pick up, the embryos were transferred at the blastocyst stage. Twelve days later to embryo transfer, serum pregnancy test was done and if positive (chemical pregnancy), the clinical pregnancy was confirmed by TVS for detection of gestational sacs and embryo cardiac activity. The ongoing pregnancy was detected by abdominal ultrasound at 12 weeks.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •age; 22-35 years,
- •BMI; less than 35 kg/m2,
- •Husband with oligo- or oligoasthenospermia.
排除标准
- •\1-gross uterine and tubal pathology,
- •2-Development of OHSS,
- •3-poor responders,
- •4-failure of oocyte fertilization or failure of the embryos to reach the blastocyst stage and
- •5-Refusal to participate in the study at any step of the ICSI cycle.
结局指标
主要结局
chemical pregnancy
时间窗: 14 day
positive pregnancy test
The ongoing pregnancy
时间窗: 3 months
was detected by abdominal ultrasound at 12 weeks.
the clinical pregnancy
时间窗: 28 day
was confirmed by TVS for detection of gestational sacs and embryo cardiac activity.
次要结局
未报告次要终点
研究者
khalid mohammed salama
principal investigator
Benha University
