Acıbadem University Medical Faculty Atakent Hospital IVF Unit
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 4
- 主要终点
- Live birth rate
研究概览
简要总结
Evaluation of follicle diameters on human chorionic gonadotrophin(hCG) day and oocyte pick up (OPU) day of follicles developing after gonadotropin treatment, the relationship between follicle diameter and maturation in oocytes obtained after OPU and its effect on pregnancy outcomes will be investigated. In order to make it easier to measure and enumerate the follicle diameters with the help of vaginal ultrasound, patients under 35 years of age with at most five follicles in any ovary and at least four follicles in both ovaries will be included in the study.
详细描述
In our study, patients with 5 and 10 follicles exceeding 11 mm will be included in order to define the follicles whose hCG day is measured more clearly on the day of OPU in patients with whom we performed controlled ovarian hyperstimulation for in vitro fertilisation(IVF). The localizations and diameters of these follicles in both ovaries will be drawn and the hCG day will be numbered and their measurements will be indicated. On the day of opu, the marked and numbered follicles will be measured, noted and aspirated one by one, the collected eggs will be followed in individually numbered culture dish and it will be evaluated whether they are mature or not prepared for microinjection. And mature oocytes will be followed in numbered culture dishes after microinjection. The relationship between hCG and OPU day follicle diameter will be evaluated by following the follicle diameter and follicle diameters on the day of egg collection, the relationship between the mature egg, the rate of reaching the blastocyst stage, the clinical pregnancy and live birth rates
Especially the relationship between mature egg and follicle diameter and the resulting clinical results may guide clinicians in practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 23 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patient group with at least 5 and at most 10 follicles in each ovary whose hCG day exceeds 11 mm,
- •Patient group with BMI below 30.
排除标准
- •PCO patient group,
- •Male factor group with severe OAT,
- •Patient group with endometriosis,
- •Patient group with PGD indication,
- •The group under the age of 40 and legally deserving of double embryo transfer
结局指标
主要结局
Live birth rate
时间窗: 15 months
live birth rate of participants
Clinical pregnancy rate
时间窗: 6 months
clinical pregnancy rate of participants
次要结局
- Oocyte maturation(6 months)