The Effects of Chronic Trans- Resveratrol Supplementation on Aspects of Cognitive Performance, Mood, Sleep, Health and Cerebral Blood Flow in Healthy, Young Humans.
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Chronic Modulation of Cerebral Blood Flow
研究概览
简要总结
The effects of chronic resveratrol supplementation have yet to be investigated in healthy humans. It is hypothesised that the effects will be different to those seen in acute supplementation. This study will look specifically at cognitive performance, cerebral blood flow, subjective sleep, mood and health, blood pressure and plasma levels of resveratrol. It is hypothesized that these measures will be affected differently by acute and chronic supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 18-35
- •At least enrolled on undergraduate degree programme
- •Native English speaker
排除标准
- •Taking other medication/ supplements
- •Pregnant/ breast feeding
- •High caffeine consumers
- •Migraine sufferers
研究组 & 干预措施
Placebo
Methyl Cellulose administered in identical capsules as the active.
干预措施: Placebo (Other)
500mg resveratrol
Transmax from biotivia. 500mg resveratrol (98% purity) with 10mg piperine per capsule. 1 capsule taken daily.
干预措施: Resveratrol (Dietary Supplement)
结局指标
主要结局
Chronic Modulation of Cerebral Blood Flow
时间窗: 40- 80 minutes post- dose on day 28 of supplementation
Cerebral blood flow (CBF) was measured in the frontal cortex with Near-Infrared Spectroscopy (NIRS). Modulation was deemed to have taken place if levels differed significantly from day 1 to day 28.
次要结局
- Number of Participants With Modulated Mood(28 days)
- Number of Participants With Modulated Cognitive Performance(28 days)
- Number of Participants With Significant Modulation of Sleep(Day 28)
- Number of Participants With Significant Modulation of Health(Day 28)
- Number of Participants With Significant Modulation of Blood Pressure(28 days)
- Number of Participants With Significant Modulation of CBF in MCA(28 days)
研究者
David Kennedy
Professor
Northumbria University