A double blind randomised controlled trial assessing the analgesic equivalency of oxycodone, paracetamol and ibuprofen with codeine, paracetamol and ibuprofen or paracetamol and ibuprofen alone in moderate pain from musculoskeletal limb injuries presenting to the emergency department.

Southern Health Emergency Research Group0 个研究点目标入组 216 人开始时间: 2010年7月21日最近更新: 2020年1月13日

适应症

试验速览

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•1) Adult patients greater than or equal to18 years old and less than or equal to 75 years old AND
•2) Limb injury within the preceding 48 hours AND
•3) Initial verbal pain score elicited by the Triage Nurse of greater than 3/10 to less than or equal to 7/10 (ie 4 to 7/10)

•Need for any time critical interventions (e.g. reduction of dislocations or compound fractures) .
•Digital injuries (pain from these should ideally be treated with digital block).
•Pregnant and breastfeeding women (paracetamol and codeine are Category A drugs but Ibuprofen and oxycodone are Category C; with regard to lactation, paracetamol and ibuprofen are considered safe, but codeine and oxycodone are not recommended).
•Asthma that may be Non-Steroidal Anti-inflammatory Drug (NSAID) sensitive.
•Active peptic ulcer disease.
•Known renal impairment.
•Ethanol or recreational drug abuse or acute intoxication.
•Use of any analgesic or sedating agent in the preceding 4 hours .
•Regular use of analgesic agents for chronic pain.
•Inability to take oral analgesics.
•Known allergy or intolerance to paracetamol, to any opiate, or to any NSAID including Aspirin.
•Patients not willing to comply with the recommendation not to drive, consume alcohol or operate machinery for at least 8 hours after being given the study drug combination.
•Patients unable to understand the study explanation or unwilling to participate for whatever reason.

发起方

Southern Health Emergency Research Group