Effects of Exercise on Physical Fitness Among Hemodialysis Patients With Chronic Kidney Disease - as Part of the Project to Implement Exercise During Hemodialysis Reference 15/10
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 主要终点
- Change from baseline in Biochemical values, Protein KLOTHO at 3 month and 6 month
研究概览
简要总结
Regular physical exercise was adapted to the situation of the patient with hemodialysis to help improve the quality of life of the patient
详细描述
It has been observed that programs that combine aerobic and resistance exercise can increase muscular strength and endurance, functional capacity and quality of life of patients in Hemodialysis. Aerobic exercise and muscular endurance during dialysis increase blood flow at the muscular level with an increase in capillary surface area, which dynamizes the flow of urea and toxins from the tissues to the vascular compartment, which could improve the effectiveness of dialysis In addition, moderate regular exercise can modulate the inflammatory response, which would be beneficial in patients with chronic kidney disease
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Famel and male between 55 - 85 year old. in hemodyalisis treatment
排除标准
- •Younger than 55 years and older than 85 years.
- •Presenting myocardial infarction in the previous 6 weeks.
- •Unstable angina to exercise or at rest.
- •Recent cerebral vascular disease or with risk of recurrence.
- •Musculoskeletal, respiratory (COPD with frequent decompensation).
- •Hypertensive disorders, patients with peripheral vascular disease,
- •Active liver disease.
- •Osteoporosis diagnosed, in which the medical criterion is contraindicated physical exercise.
- •Solution of problems of the following circumstances:
- •Fraction of cardiac ejection <of 45%, Hb <of 10gr / dl.
- •Problematic vascular access, both immature fistulas or with risk of extravasation and catheter dysfunctions of postural characteristics.
研究组 & 干预措施
Hemodyalisis patients
group of patients in hemodialysis who performs the exercise program
干预措施: Intradyalisis with exercise programe (Other)
Hemodyalisis patients
group of patients in hemodialysis who performs the exercise program
干预措施: Intradyalisis without exercise programe (Other)
结局指标
主要结局
Change from baseline in Biochemical values, Protein KLOTHO at 3 month and 6 month
时间窗: baseline, 3 month and 6 month
The measurement of Klotho in plasma (obtained from peripheral blood collected in tube with EDTA 3K anticoagulant) was performed by ELISA, with Well-wash 4 MK microplate washer (Thermo Electron Corporation) and Mutiskan EX microplate reader (Thermo Electron Corporation ), using the Human soluble α-Klotho Assay kit (Immuno-Biological Laboratories Co., Ltd, Japan). All samples were analyzed in duplicate following recommendations.
次要结局
- Change from baseline in Physical performance sit and stand at 6 month(Baseline and 6 month)
- Change from baseline in Physical performance 6MWT at 6 month(Baseline and 6 month)
- Change from baseline in Physical performance handgrip force at 6 month(Baseline and 6 month)
- Change from baseline in Mental and health status (Beck Depression Inventory) at 6 month(Baseline and 6 month)
- Change from baseline in Mental and health status (Health-related QoL <HRQoL> ) at 6 month(Baseline and 6 month)
- Change from baseline in Mental and health status (level of anxiety) at 6 month(Baseline and 6 month)
- Hemogram and Biochemical values , (hemoglobin, hematocrit and mean corpuscular volume )(Baseline)
- Hemogram and Biochemical values (Iron, albumin, calcium and phosporus)(Baseline)
- Change in Body Composition, Body mass index (BMI)(Baseline, 3 months and 6 ,months)
- Change in Body Composition, Body Fat Index(Baseline, 3 months and 6 ,months)
- Change in Body Composition, Fat Mass by body segment(Baseline, 3 months and 6 ,months)
- Change in Body Composition, Total Muscle Mass(Baseline, 3 months and 6 ,months)
- Hemogram and Biochemical values (Transferrin)(Baseline)
- Hemogram and Biochemical values (Ferritin and PTH)(Baseline)
- Hemogram and Biochemical values (The ions (Na +, K + and Cl-))(Baseline)
- Hemogram and Biochemical values (The transferrin saturation index (IST))(Baseline)
- Sociocultural aspects(Baseline)
研究者
Marcela Gonzalez Gross
Full Professor for Sport Nutrition and Exercise Physiology
Universidad Politecnica de Madrid