NCT00790725终止不适用
Proportional Assist Ventilation vs. Pressure Support Ventilation in the Management of Patients Referred to a Respiratory Acute Care Unit
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Length of time mechanically ventilated in the RACU
研究概览
简要总结
In this study, we want to compare two different kinds of artificial ventilation to see if one encourages faster weaning from breathing support and if one provides better sleep quality. These artificial ventilation types are:
- Pressure support ventilation; the standard ventilation that we use for the patients in the Respiratory Acute Care Unit. Pressure support ventilation ventilators use constant air pressure to assist patients with their breathing.
- Proportional assist ventilation; a newer way of helping people with their breathing. The air pressure provided by proportional assist ventilation ventilators varies with the size of the breath that a person takes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Tracheotomized or endotracheally intubated and mechanically ventilated patients transferred or scheduled to be transferred to the RACU.
- •Age 18 years or older.
排除标准
- •Patients who are weaned from ventilatory support within the first 72 hours of transfer to the RACU. Even though these patients had been randomized, they will be excluded. They will be considered in the intention to treat analysis but the final outcome analysis will be performed after their exclusion.
- •High spinal cord injury
- •Immunosuppressed patients receiving chemotherapy or radiation therapy (< 2 months after chemotherapy or radiation therapy).
- •Neuromuscular/ neurological disease of a progressive nature resulting in chronic ventilator dependence.
- •High risk of mortality within 3 months (severe neurological damage and cancer patients in terminal stages of the disease).
- •Patients unable to trigger the ventilator for any reason.
- •Any patient who is not considered a candidate for weaning from ventilatory support
- •Patients consented for another interventional study.
- •Patients requiring more than 30 days to wean once randomized will be excluded. They will be considered in the intention to treat analysis but the final outcome analysis will be performed after their exclusion.
结局指标
主要结局
Length of time mechanically ventilated in the RACU
时间窗: 30 days
次要结局
- Sleep quality(48 hours)
- Inflammatory mediator levels(30 days)
- Hospital mortality(30 days)
- 60 day mortality(60 days)
- 180 day mortality(180 days)
- 365 day mortality(1 year)
研究者
Robert M. Kacmarek
Professor of Anesthesia, Director of Respiratory Care Services
Massachusetts General Hospital
研究点 (2)
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