A randomized clinical trial disabling fatigue in multiple sclerosis occurs frequently. How should it be treated?

VU University Medical Center (Netherlands)0 个研究点目标入组 90 人开始时间: 2011年7月19日最近更新: 2019年2月11日

适应症

试验速览

2013 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/23938046 2. 2015 results in https://www.ncbi.nlm.nih.gov/pubmed/25789625 (added 24/01/2019) 3. 2016 results of real-time assessment of fatigue in patients with multiple sclerosis. In https://www.ncbi.nlm.nih.gov/pubmed/27233157 (added 24/01/2019) 4. 2016 results of the effectiveness of cognitive behavioural therapy for the treatment of fatigue in patients with multiple sclerosis. In https://www.ncbi.nlm.nih.gov/pubmed/27772557 (added 24/01/2019) 5. 2016 results of the role of appraisal and coping style in relation with societal participation in fatigued patients with multiple sclerosis. In https://www.ncbi.nlm.nih.gov/pubmed/27372714 (added 24/01/2019) 6. 2017 results of the effectiveness of cognitive behavioural therapy to improve MS-related fatigue and participation. In https://www.ncbi.nlm.nih.gov/pubmed/28528567 (added 24/01/2019) 7. 2017 results of which psychological factors mediate change in fatigue during and after cognitive behavioural therapy. In https://www.ncbi.nlm.nih.gov/pubmed/29455894 (added 24/01/2019) 8. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29313870 (added 24/01/2019)

•Ambulatory MS patients fulfulling the following enrollment criteria:
•1. Diagnosis of MS according to the criteria of McDonald
•2. Able to walk with no more than one unilateral walking aid i.e. able to walk with no more than one unilateral walking aid
•3. Suffering from fatigue, defined as a score higher than 35 on the subscale fatigue of the Checklist Individual Strength (CIS)
•4. Age between 18-70 years

•1. Patients using in the last three months prior to inclusion Amantadine, Modafinil, Ritalin or Pemoline for their fatigue
•2. Major depression

发起方

VU University Medical Center (Netherlands)