NCT02750046Unknown不适用
Collection of Bone Specimens for Testing of A Special Vessel Subtype
Second Affiliated Hospital of Soochow University1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2016年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The area of a special vessel subtype in human bone samples
研究概览
简要总结
RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to study a special vessel subtype in the laboratory may help surgeon learn more about the relationship between bone mineral density (BMD) and a special vessel subtype (type H vessel).
PURPOSE: This research study is looking at changes of a special vessel subtype in bone samples from patients with osteoporotic and nonosteoporotic fracture.
详细描述
OBJECTIVES:
- Establish type H vessel in bone specimen in patients with hip fracture.
- Explore the correlation of BMD and type H vessel.
OUTLINE:
- Collect human bone specimens from patients with Osteoporotic and Nonosteoporotic Fracture.
- Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators.
- Observe the type H vessel in bone slice by immunofluorescence staining.
- Collect clinical data on these patients including bone mineral density.
- Investigate the relationship between BMD and type H vessel.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Ages Eligible for Study: 65-75 Years
- •Genders Eligible for Study: Woman
- •Accepts Healthy Volunteers: NO
- •Study Population: Female patients with hip fracture. -
排除标准
- •Malignancy or benign ovarian cysts
- •Known chronic or systemic diseases
- •Hormone therapy in the previous 3 months
- •Bone metabolism and drug therapy
结局指标
主要结局
The area of a special vessel subtype in human bone samples
时间窗: 3 months
Bone samples were fixed in 4% PFA, decalcified, dehydrated, embedded and immunofluorescent staining for 3 months. Calculate the proportion of the special vessel of total vessel.
次要结局
- The value of bone mineral density(1 week)
- Correlation of of bone mineral density and area of a special vessel subtype in human bone(2 months)
研究者
研究点 (1)
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