Ocular Changes After Selective Alpha-2 Receptor Agonist.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Intraocular pressure
研究概览
简要总结
selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.
详细描述
In this research, we will analyze the effect of selective alpha-2 receptor agonists on the human eye and investigate ocular changes over 6 months after its topical use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Glaucoma suspect cases.
- •post-refractive surgery cases.
排除标准
- •Cases with prostatic hyperplasia or diabetics that may alter the measurements of pupillary diameter.
- •Cases with previous history of any retinal intervention or other drugs that may alter intraocular pressure measurements.
研究组 & 干预措施
Glaucoma suspect group
Cases diagnosed as glaucoma suspect
干预措施: Low dosage selective alpha-2 receptor agonists topical eyedrop (Drug)
Glaucoma suspect group
Cases diagnosed as glaucoma suspect
干预措施: High dosage selective alpha-2 receptor agonists topical eyedrop (Drug)
Post-refractive surgery group
Cases had undergone refractive surgery
干预措施: Low dosage selective alpha-2 receptor agonists topical eyedrop (Drug)
Post-refractive surgery group
Cases had undergone refractive surgery
干预措施: High dosage selective alpha-2 receptor agonists topical eyedrop (Drug)
结局指标
主要结局
Intraocular pressure
时间窗: Baseline and 6 months after regular use of the topical eyedrops
Changes in intraocular pressure measured in mmHg by applanation tonometry
次要结局
- Pupillary diameter(Baseline and 6 months after regular use of the topical eyedrops)
研究者
Ahmed Abdelshafy
Assistant professor of Ophthalmology
Benha University