Treatment Endpoints in Acute Decompensated Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 835
- 试验地点
- 2
- 主要终点
- Heart-failure related adverse events
研究概览
简要总结
The purpose of this study is to determine if certain findings (blood tests, symptom improvement, etc.) after acute heart failure treatment can identify a group of patients who are safe for early hospital discharge.
详细描述
A fundamental question faced by physicians treating acute decompensated heart failure (ADHF) is "When has treatment worked sufficiently for safe discharge, and who requires further treatment?" Patients with ADHF have a high incidence of morbidity and mortality. Current guidelines for emergency department (ED) and hospital disposition of patients with ADHF are based on limited empirical evidence. This creates clinical uncertainty regarding disposition leads to prolonged hospitalizations, higher costs and increased resource consumption. The specific aim of the study is to develop a prediction rule from readily available clinical data to help physicians identify ADHF patients eligible for safe and early discharge from the ED and hospital after treatment is initiated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fulfill the modified Framingham criteria
- •Have baseline data available within 1 hour of initial ED therapy
- •Have previously documented systolic dysfunction (ejection fraction less than 50%) by echocardiogram
- •Willing and able to give informed consent
- •The exclusion criteria are:
- •Patients less than 18 years of age.
排除标准
- 未提供
结局指标
主要结局
Heart-failure related adverse events
时间窗: Measured 5 days and 30 days after ED presentation
次要结局
未报告次要终点
研究者
Sean Collins
Associate Proffesor of Emergency Medicine
Vanderbilt University
