Typing of endometrial lymphocytes of (unexplained) recurrent miscarriage patients - TERM-study

Radboud Universitair Medisch Centrum0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年4月15日

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•Patient group:
•Normotensive women aged 18-45 years with a history of 3 or more consecutive, idiopathic pregnancy losses before <20 weeks of pregnancy. Patients are asked to collect menstrual blood. In case of a recent miscarriage, the patient is asked to collect menstrual blood during their second normal menstruation following the miscarriage.;Control group: Normotensive, fertile women aged 18-45 years without any known pregnancy complications, i.e. not tried to conceive yet and/or no problems to get pregnant and uncomplicated pregnancies.;The partner, i.e. biological father of the child, of these women will be included in the study as well.

•- Use of immunosuppressive drugs, biological or antidepressants
•- Use of birth control (exception condom)
•- HIV positivity
•- Auto-immune diseases
•- Diabetes mellitus
•- Participants who are not capable of signing the informed consent
•- Patients will be excluded if there is a known cause for the miscarriages like e.g. the presence of anti-thyroid, anti-phospholipid and anti-nuclear autoantibodies, endocrine dysfunction, uterine malformation, hemostatic disorder, and abnormal karyotype.

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