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临床试验/NCT02506205
NCT02506205Unknown不适用

The Effect of LSVT LOUD for Mandarin-speaking Individuals With Hypokinetic Dysarthria Due to Parkinson's Disease

National Taiwan University Hospital2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2014年10月最近更新:
适应症

试验速览

阶段
不适用
入组人数
40
试验地点
2
主要终点
Speech intelligibility

研究概览

简要总结

A handful of studies have examined the effects of the Lee Silverman Voice Treatment (LSVT) LOUD on hypokinetic dysarthria in English speakers with Parkinson's disease (PD). Although LSVT LOUD has been found to be effective on improving these speaker's vocal intensity and increasing their speech intelligibility as well as speech function with Phase I evidence, no study has investigated whether Mandarin-speaking individuals with dysarthria secondary to PD would benefit from LSVT LOUD. In the proposed study, speech data of Mandarin-speaking individuals with hypokinetic dysarthria before and after speech therapy will be audio recorded and analyzed in order to examine the effects of LSVT LOUD on the speech function in this population. The same speech data will be played to Mandarin listeners in order to investigate the speech intelligibility of this population. It is hypothesized that Mandarin-speaking individuals with hypokinetic dysarthria secondary to PD will demonstrate reduced vocal intensity, reduced speech intelligibility and impaired speech function before they receive LSVT LOUD. They will improve these speech characteristics following speech therapy and will present with short-term maintenance effects.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
30 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Mandarin-speaking Taiwanese
  • Hypokinetic dysarthria due to Parkinson's disease
  • No other neurodegenerative diseases
  • No cognitive deficits
  • Age range 30 years and above

排除标准

  • Not able to follow verbal directions,
  • speech characteristics uncommon to Parkinson's disease

结局指标

主要结局

Speech intelligibility

时间窗: Immediate

Speech intelligibility will be assessed by native Mandarin listeners' orthographic transcription accuracy and ratings based on a nine-point Likert scale (from 1 - very difficult to understand to 9 - very easy to understand).

次要结局

  • Speech function(Immdediate)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

National Taiwan University Hospital

National Taiwan University Hospital

National Taiwan University Hospital

研究点 (2)

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