Genetic Investigation of Solid Tumors Cohort
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Solid tumor biological insights
研究概览
简要总结
The objective of this study is to obtain blood samples, solid tumor and/or benign hyperplasia samples to learn more about genetic differences that are linked to the formation of solid tumors.
详细描述
Recent studies in human genetics have discovered several intervals in the human genome containing inherited variants that are statistically associated with the propensity to develop solid tumors. Even though it has been firmly established that if an individual carries these DNA variants they have an increased chance of developing a solid tumor the underlying biological mechanisms for most of these associations are largely unknown.
In addition to inherited DNA variants that are associated with the development of solid tumors it is well established that during the development and growth of solid tumors the DNA in these cancer cells undergo somatic changes (mutations). These somatic DNA changes have been studied over the past decade and frequently are specific chromosomal translocations and amplifications associated with the development of particular solid tumors. In some instances, examining the chromosomal translocation and amplification has lead to the discovery of proteins contributing to solid tumor pathology.
the human 8q24 interval that has strong genetic associations with solid tumor development has also been noted as frequently amplified in solid tumors and serves as a predictor of poor survival in prostate cancers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Eligible to have their blood drawn
- •Be reliable, cooperative and willing to comply with all protocol-specified procedures
- •Able to understand and grant informed consent
- •Diagnosis of a solid tumor
排除标准
- •Has a significant chronic medical condition which would potentially confound interpretation of the individual's phenotype.
- •Treatment with any investigational agents or devices within thirty days preceding enrollment in the study.
- •Been administered or taken any CNS sedatives or depressants in the 12 hours prior to informed consent process
结局指标
主要结局
Solid tumor biological insights
时间窗: Study completion
Obtain blood samples, solid tumor and/or benign hyperplasia samples, and in some instances normal tissue in order to gain biological insights into cancer (solid tumors) through population genetics and genomics.
次要结局
未报告次要终点
研究者
Eric Topol, MD
Director
Scripps Translational Science Institute