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临床试验/CTRI/2014/06/004666
CTRI/2014/06/004666已完成不适用

Effects of red raw and red parboiled rice on the glycemic control in type 2 diabetes mellitus patients

University of Sri Jayewardenepura1 个研究点 分布在 1 个国家目标入组 69 人开始时间: 2010年1月10日最近更新:

试验速览

阶段
不适用
状态
已完成
入组人数
69
试验地点
1
主要终点
Improvement in BMI, Lipid profile and Blood glucose levels

研究概览

简要总结

Identifying a healthy rice variety has substantial health benefits for type two diabetes mellitusxml:namespace prefix = o /

Patients (T2DM). Parboiled rice consumption is known to reduce glycaemic response. Neither

glycaemic responses, nor lipid profile, BMI in diabetes after consumption of red parboiled and red raw rice has been explored. Aim of this study was to determine the impact of red parboiled rice consumption vs to red raw rice on glycaemic response, lipid profile  and BMI in T2DM. This analytical crossover study included diabetics (aged 40-70yrs) registered at Prison Hospital, Sri Lanka.  The 69 subjects who completed  the study were served 180g of red raw in the first 16weeks and red parboiled rice in the next 16 weeks.

Two ml each of venous blood was collected after an overnight fast at 0,4,8,16 weeks for fasting

blood glucose  and at 0, 16 weeks for glycated haemoglobinand lipid profile  respectively.BMI was assessed weekly. Results while consuming red raw and red parboiled rice were compared using ANOVA repeated measures, General Linear Model.During consumption of red raw rice the BMI  (p=0.009) and fasting blood glucose (p= 0.001)reduced only at 8weeks. During consumption of red parboiled rice fasting blood glucose  reduction was significant at 8weeks (p=0.006), 12 weeks ( p=0.002), and 16 weeks (p=0.005) whereas BMI showed a significant reduction at 8 weeks (p=0.028) and 16 weeks (p=0.003). At the end of 16weeks  consumption of red parboiled rice  the LDL, TC, TC/HDL value was significantly lower respectively (p= 0.001, p= 0.013, p=0.032) whereas none of the lipid markers were altered while consuming red raw rice. These results suggest that red parboiled rice consumption could be used as a novel approach in reducing the  glucose, lipid metabolism markers and BMI   in diabetes mellitus.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Not Applicable

入排标准

年龄范围
35.00 Year(s) 至 75.00 Year(s)(—)
性别
All

入选标准

  • Suffering from type II diabetes mellitus.

排除标准

  • •Those who were on treatment for any diseases such as diabetes, hypertension, hypercholesteraleamia were excluded from the study when their medications were changed due to any reason.
  • •Advanced complications of diabetes, such as retinopathy with laser treatment, neuropathy with renal impairment and extensive diabetic ulcers.
  • •Those who receive insulin therapy.
  • •Those who did not consume rice as the staple food.
  • •Patients who did not understand English and/or Sinhala language.

结局指标

主要结局

Improvement in BMI, Lipid profile and Blood glucose levels

时间窗: Improvement in BMI (to below 23, Lipid profile (to normal levels for HDL, LDL, Total cholesterol, HDL:TC ratio and triglycerides) and Blood glucose levels (below 110mg/dl)at the end of 4, 8, 12 and 16 weeks of consuming the two rice varieties

次要结局

  • Improvement in BMI, Lipid profile and Blood glucose levels(At the end of 4, 6, and 12 weeks)

研究者

申办方类型
Other [University of SriJayewardenapura,Sri Lanka]

研究点 (1)

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