Emotion Study -- Improving Neural Dysregulation in Advanced Age: A Neurofeedback Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Increased activation of anterior insula from pre-training to post-training
研究概览
简要总结
This study will determine whether brain activity can be modified and improves performance on a task by showing participants live 'video feed' of their brains on advanced imaging technology. The study is particularly interested in brain regions that have been shown to be relevant for emotions, specifically the anterior insula and the medial prefrontal cortex. Advanced technology will map the brain using magnetic pulses with a real-time functional Magnetic Resonance Imaging (rt-fMRI) machine.
详细描述
Overview: All participants of both age groups will be randomly divided (like tossing a coin) into two groups:
- One group will have training sessions using a special feedback technique to learn to actively increase blood flow in the front of the brain, while thinking of and viewing emotional faces, scenes, and text
- The other group will have training sessions using a special feedback technique to learn to actively increase blood flow in the back of the brain while thinking of and viewing emotional faces, scenes, and text
Further, each of these two groups will be divided into two sub-groups that are different with respect to the training procedure that is used:
* Use of a 3.0 Tesla, 32-channel Seimens whole-body human MR scanner (fMRI) during training, that has not been associated with any known side effects or safety risks
Number of Study Visits:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18-30 years or 63-90 years
- •Right-handed
- •Native English speaker
排除标准
- •Pregnant or possibly pregnant
- •Claustrophobia
- •Large pieces of metal in the body, particularly in the face and neck.
- •Piercings or metal implants that cannot be removed from the body
- •Surgery on the brain or any prior serious brain damage or disease
- •Dementia or severe cognitive disorders
结局指标
主要结局
Increased activation of anterior insula from pre-training to post-training
时间窗: Pre-training session (baseline visit); post-training session (approximately one week later)
Both young and older participants can be trained in up-regulation of anterior insula activity, by means of contingent neurofeedback (rt-fMRI), reflecting continued plasticity of brain regions associated with affective processing.
次要结局
- Gained volitional control over activity in anterior insula improves emotion perception from pre-training to post-training(Pre-training (baseline visit); post-training visit (approximately one week later))