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临床试验/NCT01759914
NCT01759914终止不适用

Intraocular Pressure in Corticosteroid-treated Dermatology Patients

University Hospitals Coventry and Warwickshire NHS Trust1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2012年9月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
终止
入组人数
25
试验地点
1
主要终点
Change in intraocular pressure from baseline

研究概览

简要总结

Ocular hypertension and glaucoma are eye conditions associated with abnormally high fluid pressure in the eye (called intraocular pressure or IOP). If left untreated, the elevated IOP may eventually cause damage to the nerve of the eye and potential impairment of vision.

The use of certain drugs has been identified as a risk factor for raised IOP, including various forms of administration of corticosteroids. Corticosteroids can also lead to cataract, which is clouding of the lens in the eye that can affect vision.

In this research study, we would like to find out whether the use of corticosteroids in our dermatology clinic leads to raised IOP, in order to identify patients at risk and to allow them to be more closely monitored than others. It is important to identify those patients who have a corticosteroid-induced pressure rise early enough to prevent them from permanent glaucomatous visual loss.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients on whom corticosteroid treatment is being introduced for a duration of at least 12 weeks

排除标准

  • pregnant women
  • patients already under glaucoma treatment
  • patients unable to give informed written consent or those unable to cooperate fully with the assessments

研究组 & 干预措施

Potent topical steroid-treated

Patients treated with potent topical steroids

干预措施: Potent topical steroid (Drug)

Superpotent topical steroid-treated

Patients treated with superpotent topical steroids

干预措施: Superpotent topical steroid (Drug)

结局指标

主要结局

Change in intraocular pressure from baseline

时间窗: after 1, 2 and 3 months

Measurements will be done at 28 (+/- 7 days) days, 56 (+/- 7 days) days, and 90 (+/- 7 days)days after initiation of topical steroids.

次要结局

  • Whether there is any clinical evidence of cataract at the final visit of the study.(After 1, 2 and 3 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Yasaman Mansouri, MD

Specialist Registrar in Dermatology

University Hospitals Coventry and Warwickshire NHS Trust

研究点 (1)

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