Mechanisms of Exacerbation of Asthma
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma
研究概览
简要总结
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.
详细描述
In this study, we will explore mechanisms of exacerbation in asthma by careful characterization studies in asthmatics presenting in acute severe exacerbation. Specifically, we will determine the frequency of secretor status in these subjects by blood and saliva testing, and we will also perform a detailed cellular and biochemical analysis of their airway secretions. We will collect airway secretions using two methods. One method will be to have subjects cough sputum into a clean plastic container. The other method only applies to asthmatics with near-fatal asthma requiring intubation and mechanical ventilation. In these asthmatics, we will collect airway secretions by tracheal aspirate using methods normally applied in their clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female subjects with a history of asthma between the ages of 18 to 75 years.
- •Physician diagnosis of asthma.
- •Currently experiencing an acute exacerbation of asthma. This exacerbation may be severe necessitating treatment in the emergency room, ICU, or hospital ward.
- •Ability to provide informed consent.
排除标准
- •Lung disease other than asthma.
- •Females who are lactating or who are pregnant.
- •Use of recreational drugs in the 1 month preceding the study.
研究组 & 干预措施
Asthma
People who have been diagnosed with Asthma
结局指标
主要结局
rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma
时间窗: 1-2 years
次要结局
未报告次要终点