Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Mean arterial pressure
研究概览
简要总结
This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.
详细描述
Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.
Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 65 years.
- •Both sexes.
- •American Society of Anesthesiology (ASA) physical status I-II.
排除标准
- •Severe cardiovascular problems.
- •Respiratory disorders.
- •Diabetes.
- •Hypertension.
- •Allergic reaction to study drugs.
- •Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
- •Medications that affect heart rate (HR) or blood pressure (BP).
- •Pregnant.
- •Currently breast-feeding women.
- •History of sleep apnea.
- •Those for emergency procedures.
研究组 & 干预措施
Group D20
Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.
干预措施: Dexmedetomidine (Drug)
Group D10
Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.
干预措施: Dexmedetomidine (Drug)
Group C
Patients will receive saline before induction of anesthesia as a control group.
干预措施: Saline (Drug)
结局指标
主要结局
Mean arterial pressure
时间窗: Till the end of the surgery (Up to 2 hours)
Mean arterial pressure will be recorded at baseline, before induction, after induction, before intubation, after intubation, at 5 minutes, 10 minutes, 15 minutes, and then every 15 minutes until the end of surgery.
次要结局
- Need for intraoperative fentanyl(Intraoperatively)
- Heart rate(Till the end of the surgery (Up to 2 hours))
- Incidence of adverse events(24 hours postoperatively)
研究者
Mohammed Said ElSharkawy
Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University