Cardiac Autonomic Dysfunction As a Sign of Irreversible Advanced Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- number of rehospitalizations
研究概览
简要总结
The main hypothesis is that autonomic dysfunction cannot improve among patients reaching end-stage heart failure. To evaluate this, patients admitted with acute decompensated heart failure in Bispebjerg hospital, and history one or more admissions with the same condition within the prior year, will undergo repeated brief heart monitoring (10 min). Baseline recordings (at admission) will be compared with equivalent measurements before discharge to explore whether heart rate variability increases. Patients will be followed for six months after discharge from the hospital.
详细描述
If the patient accepts to participate and signed the project informed consent, their clinical record will be followed until the last patient included has been followed for six months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-years age or older
- •admitted with acute decompensated heart failure for less than 48 h
排除标准
- •pacemaker
- •not signed informed consent
- •other heart rhythm than sinus rhythm or atrial fibrillation
结局指标
主要结局
number of rehospitalizations
时间窗: up to six months after discharge from index admission
number of emergency rehospitalizations, classified according to: 1. new decompensation of heart failure 2. side effects / complications to therapy for heart failure 3. other
次要结局
- Heart rate Variability change from admission to discharge(repeated measurement at baseline (within 48h from time of index admission) and before discharge (estimated one week on average from index admission))
研究者
Helena DOMINGUEZ
MD, PhD, Consultant, Assoc.Prof.
University Hospital Bispebjerg and Frederiksberg