NCT06356376招募中不适用
The Effects of Pain and Pain Relief on Peripheral Nerve Excitability
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- C-fiber excitability
研究概览
简要总结
This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.
The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy Participants able to give informed consent.
排除标准
- •Chronic pain conditions
- •Neurological or Psychiatric disease
- •Other major diseases
- •Pain medication within the last 24 hours
结局指标
主要结局
C-fiber excitability
时间窗: Through study completion, an average of 6 months
Changes in C-fiber excitability measured in latency changes after electrical stimulation with a paired pulse protocol compared to an unpaired electrical stimulus.
次要结局
- Action potential duration (ms)(Through study completion, an average of 6 months)
- Heart-rate variability (ms)(Through study completion, an average of 6 months)
- Blood pressure variability (mmHg)(Through study completion, an average of 6 months)
- Action potential amplitude (V)(Through study completion, an average of 6 months)
- Sympathetic Skin Response (V)(Through study completion, an average of 6 months)
研究者
研究点 (1)
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