A CLINICAL MANAGEMENT OF DAUS SADAF/TAQASHUR-E-JILD (PSORIASIS) WITH UNANI MEDICINE
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- PSAI(PSOIARIASIS AREA AND SEVERITY INDEX ) WILL BE USED BEFORE AFTER THE TREATMENT TO RULE OUT THE OUT COME
研究概览
简要总结
DAUS’SADAF/TAQASHUR-E-JILD (PSORIASIS) Is a noninfective papulo sqamous skin disease, characterized by well defined Erythematous plaques withshiny slivery scales.
Synonyms :- Unani : Dausadaf/Taqashur-e-jild
English: Psoriasis
Hindi: Chambal
In our Unani concept our Ancient physiciansuggest that there might be excess accumulation of Abnormal sauda and saframutahirqa(jala huwa safra) into the skin.
One of our famous Unani physician BUQRAT (HIPPOCRATES,372-462 BC) Describe the skin disease but not specifies the term Psoriasis butmentioned similar Sign and Symptoms of Psoriasis.
JALINOS (129-200 year) and IBN-E-RASHED(1126-1198 year) stated that the Daus’sadaf (psoriasis) is a type of leprosyand also desribed that excess quantity of Abnormal black bile caused chronicskin disease such as Daus’sadaf & leprosy.
There are two key factors which play aimportant role in aetiology of Psoriasis
-
Autoimmune:- Naïve T cells, IL12 & IL23
-
Genetic factors:- Family history found upto30%
HLA-BW17- High familal tendency
HLA-BW13- Appear to have mild effects & h/oStreptococcus infection
HLA-BW22- Strongly Associated with Psoriasis
HLA-BW38- with exhibiting Psoriasis &distal Arthritis.
Triggering factors includes:- stress, trauma,allergens, medication reactions.
Many changes occur in the skin
Epidermis:-
Acanthosis:- Increase thickness of stratumspinosum & granulosum seen in psoriasis.
Parakeratosis:- nucleated cells seen stratumcorneum.
Dermis:-
Capillaries are dilated, twisted, closer to thesurface of the skin.
Large number of inflammatory cells are presentin all layers of the skin.
Langerhan cells and lymphocytes are alsoincreased.
The main abnormality is the increased epidermalcell turn over.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •AUSPITZ SIGN POSITIVE Patient suffering from plaque psoriasis with in 1 year.
排除标准
- •Pregnancy and lactating women patient suffering from psoriasis more than(>) 1 year Comorbidity patients(i.e D.M,CKD,CVA,IHD) MENTALLY RETARD PATIENT CA PATIENTS.
结局指标
主要结局
PSAI(PSOIARIASIS AREA AND SEVERITY INDEX ) WILL BE USED BEFORE AFTER THE TREATMENT TO RULE OUT THE OUT COME
时间窗: 51 DAYS TREATMENT FOR EACH PATIENT i.e(21 days medicated decoction od, 30 days blood purifiers bd) local application through out the treatment.
次要结局
- PSAI(PSOIARIASIS AREA AND SEVERITY INDEX ) WILL BE USED BEFORE AFTER THE TREATMENT TO RULE OUT THE OUT COME(51 DAYS TREATMENT FOR EACH PATIENT i.e(21 days medicated decoction od, 30 days blood purifiers bd) local application through out the treatment.)