NCT02371044已完成不适用
Point-of-Care Testing of Coagulation in Patients Treated With Direct Oral Anticoagulants 1
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Effect/Correlation of direct oral anticoagulants (DOAC) on CoaguChek point-of-care testing (POCT) result
研究概览
简要总结
The investigators study aims to test the correlation between the CoaguChek point-of-care testing (POCT) device (Roche, Switzerland) and low plasma levels of all three currently approved direct oral anticoagulants (DOAC; rivaroxaban, apixaban and dabigatran) and to determine the diagnostic accuracy of POCT to rule out or detect relevant levels of DOAC in real-life stroke patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stroke patients, who were newly started on oral anticoagulation with rivaroxaban, apixaban or dabigatran for secondary prevention of thromboembolic events
- •Age ≥ 18 years
排除标准
- •Vitamin K antagonists or direct oral anticoagulants ≤ 14 days prior to study participation
- •Low-molecular weight heparin ≤ 24 hours
- •Unfractionated heparin ≤ 12 hours
- •Abnormal coagulation values at baseline (Quick < 70% or activated thromboplastin time (aPTT) > 40sec.)
- •History of coagulopathy
结局指标
主要结局
Effect/Correlation of direct oral anticoagulants (DOAC) on CoaguChek point-of-care testing (POCT) result
时间窗: 24 hours
DOAC concentrations determined by ultra-performance liquid chromatography-tandem mass spectrometry
次要结局
- Diagnostic accuracy of the CoaguChek POCT to rule out or detect relevant DOAC levels(24h)
- Effect/Correlation of DOAC on prothrombin time (PT), activated thromboplastin time (aPTT), anti-Xa activity and Hemoclot assay(24h)
研究者
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