Comparison Between Intrathecal and Intravenous Morphine for Perioperative Pain Management Following Laparoscopic Nephrectomy on quality of recovery- A Randomized control Trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- quality of recovery, assessed by Quality of Recovery15 (QoR-15) scale at 24 h postoperatively
研究概览
简要总结
It is hypothesized that a single dose of intrathecal morphine (ITM) combined with intravenous analgesic has advantages forperioperative pain control in order to decreased systemic opioid use and overall quality of recovery would be improved as comparedwith IV-morphine with intravenous analgesics. patients will be divided into two groups, first group will receive intra thecal morphine before induction and the other group will receive intra venous morphine before induction. standardized routine IV analgesics will be given to both the groups post-operatively. tramadol will be given as rescue analgesia. Patients will be assessed by using 15-point quality of recovery score, higher the score better will be the quality of recovery. net opioid consumption will be calculated 24 hours post-operatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society of Anesthesiologists (ASA) physical status I to III, and body mass index between 18 and 35 kg/m2.
排除标准
- •: inability to consent to the study, coagulopathy, sepsis, hepatic or renal failure, allergy to local anesthetic (LA), pregnancy, and opioid intake at home.
结局指标
主要结局
quality of recovery, assessed by Quality of Recovery15 (QoR-15) scale at 24 h postoperatively
时间窗: 24 hours
次要结局
- incidence of side effects like pruritus, sedation, respiratory depression, urinary retention.(24 hours)