Effects of Adapted Tango on African-American Women Caregivers of Alzheimer's Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Change in Interleukin-10
研究概览
简要总结
The goal of the project is to determine the extent to which indices of inflammatory biomarkers, cognition and mood, are influenced by a partnered, dance-based intervention vs control condition in African American (AA) female family caregivers, at high risk for Alzheimer's disease (AD).
详细描述
The importance of informal family caregiving in Alzheimer's disease (AD) is well-established. African-American caregivers are most often middle aged adult children of AD patients (vs. spouses), women, and are at higher risk for chronic health problems. AD lifestyle interventions offer an alternative to medication, and are generally affordable, accessible, and adaptable to the lives of caregivers. To date, most non-pharmaceutical interventions have focused on exercise and nutrition, both of which have proven to be highly successful in conferring AD related benefits and decreasing AD risk.
The goal of the project is to determine the extent to which indices of inflammatory biomarkers, cognition and mood, are influenced by a partnered, dance-based intervention vs control condition in African American (AA) female family caregivers, at high risk for Alzheimer's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women family caregivers from the Emory ADRC and Dr. Wharton's studies of Alzheimer's disease (AD) caregivers
- •Parental diagnosis 'probable AD'
- •African-American
- •45-65 years of age
排除标准
- 未提供
研究组 & 干预措施
Adapted Tango Dance
20 improvisational, 90-minute adapted tango dance sessions over a 12-week period.
干预措施: Adapted Tango Dance (Other)
Educational Control
Participants will take part in at least 20 educational lectures offered twice per week over 12 weeks.
干预措施: Educational lectures (Behavioral)
结局指标
主要结局
Change in Interleukin-10
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in tumor necrosis factor alpha
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in C-reactive protein
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in monocyte chemoattractant protein 1
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in macrophage derived chemokine
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in transforming growth factor alpha
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in interleukin-7
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in interleukin-8
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in interleukin-9
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in interferon induced protein 10
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
Change in serum amyloid protein
时间窗: Before and after the intervention / control at least 20 times during 12 weeks
45 mL blood will be acquired before and after the intervention to measure the inflammatory and stress marker levels
次要结局
- Change in the Tower of London test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Buschke Selective Reminding Test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in the Stroop interference test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in the Body position spatial task (BPST)(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Fullerton Advanced Balance Scale(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in 30-second chair stand(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Montreal Cognitive Assessment (MoCA)(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Brooks spatial memory test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in the Center for Epidemiologic Studies Depression Scale (CES-D)(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in DEMQOL: Dementia Quality of Life measure (Carer v4)(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Reverse Corsi Blocks test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Trails B test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Digit Span test(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in gait speed(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in the Zarit Burden Interview(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Pearlin Caregiver Stress Scale(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
- Change in Positive Aspects of Caregiving (PAC) Scale(Before and after the intervention / control, offered twice per week, at least 20 times during 12 weeks)
研究者
Madeleine Eve Hackney
Assistant Professor
Emory University