The Effect of Moderate Alcohol Consumption on Markers of Oxidative Phosphorylation and Lipid Oxidation and on Postprandial Glycemic Control in Healthy, Lean and Overweight, Young Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 主要终点
- enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle
研究概览
简要总结
Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption. Patients with diabetes type 2 or impaired glucose tolerance often may have decreased fat oxidative capacity or oxidative phosphorylation in tissue such as muscle. This could lead to accumulation triglyceride storage in muscle, which could interfere with insulin signaling. Whether such mechanism can also play a role with moderate alcohol consumption is unknown and will be investigated in this study.
In addition, moderate alcohol consumption with a meal can lead to delayed hypoglycemia in type 1 diabetes patients. How moderate alcohol consumption affects postprandial glycemic response in healthy subjects is unknown. This is a secondary objective of this trial.
详细描述
To investigate the effect of moderate alcohol consumption on
- enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle
- transporters of fatty acids and glucose in fat tissue
- post-prandial glycemic response in healthy, lean or overweight, young men
Design : Open, randomized, partially diet-controlled, placebo controlled cross-over design
Participants
- Description : Healthy, lean and overweight young (18-40 years) men
- Number : 20
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy men aged between 18 and 40 years
- •Lean subjects BMI 18.5-25 kg/m2 and overweight/obese subjects BMI >27 kg/m2 (including 18.5, 25 and 27)
- •Alcohol consumption between 7 and 28 units/week (including 7 and 28)
排除标准
- •Family history of alcoholism
- •History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
- •Recent blood donation
- •More than 8 hours/week of intense exercise
- •Blood haemoglobin concentration below 8.4 mmol/l
- •Allergic to betadine or lidocaine.
结局指标
主要结局
enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle
时间窗: 4 weeks
次要结局
- Post-prandial glycemic response(4 weeks)
- insulin sensitivity (oral glucose tolerance test) and related factors (adiponectin, HbA1c)(4 weeks)