Evaluation of Intestinal Secretion of Antibodies and Auto-antibodies Associated With Crohn's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Compare the performances of the dosage of the ASCA in floating it of culture of intestinal biopsies in that of their dosage in the serum
研究概览
简要总结
We propose to study the intestinal secretion of ASCA by evaluating them in biopsy culture supernatants from a cohort of patients suffering from CD (n=80) and a cohort of control patients (UC (n=40) and patients without IBD (n=40 )).
详细描述
Its diagnosis is based upon clinical, endoscopic and histological parameters but recent studies have shown that seric evaluation of immunological markers (anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic auti-antibodies (ANCA)) could be useful. Crohn's disease (CD) is an inflammatory bowel disease (IBD) of the young people. Antibodies anti-chitobisoside carbohydrate (ACCA), anti-laminaribioside carbohydrate (ALCA) and anti-mannobioside carbohydrate (AMCA) have been described as new serological markers of CD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients reached by disease of crohn
- •patients reached by hemorrhagic first side-colitis
排除标准
- •Forms ileales or ano-périneales pure of disease of crohn
- •indefinite colitis
研究组 & 干预措施
1
Patients with crohn disease
干预措施: Blood sampling and biopsy (Other)
2
Patients reached by hemorrhagic first side-colitis
干预措施: Biopsy and blood sampling (Other)
3
Patients controls
干预措施: Biopsy and blood sampling (Other)
结局指标
主要结局
Compare the performances of the dosage of the ASCA in floating it of culture of intestinal biopsies in that of their dosage in the serum
时间窗: 24 months
次要结局
- Determine if the patients reached by disease of crohn not presenting ASCA in their serum represent one under group of disease of crohn(24 months)