The Use of a Forecasting System for Predicting Exacerbations of COPD: Effect on Symptoms and Hospitalisation and Relevance of Viral Infections
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- The incidence and frequency of COPD exacerbations in each of the intervention groups
研究概览
简要总结
People with Chronic Obstructive Pulmonary Disease (COPD) often have periods during the year when their symptoms become worse. These are often due to an infection and are called "exacerbations" by doctors. Exacerbations are more common in the winter and also seem to be related to particular types of weather. As well as forecasting the weather the UK Met Office has developed a system to try to predict when exacerbations are likely to occur. The main purpose of this research study is to find out whether the Met Office forecasting service can predict when exacerbations are more likely to occur and whether the advice given during the predicted higher risk periods leads to fewer patients having an exacerbation or if it reduces the impact of the exacerbation. The study will also assess if there is a link between viral or bacterial infection and breathing problems that occur during the study period. The study will also collect information about possible causes of the breathing problems and what happens to the person afterwards. The results of this study will help us learn more about breathing problems which may lead to new research studies that would aim to improve the care of people with COPD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Current or former smokers with a diagnosis of COPD
- •Having impaired lung function as measured by spirometry
排除标准
- •History of asthma or nasal symptoms caused by hayfever
- •No telephone
- •Inability to record symptoms in an electronic diary (PDA)
结局指标
主要结局
The incidence and frequency of COPD exacerbations in each of the intervention groups
时间窗: December 2008 to March 2009 inclusive
Electronic diary symptoms using the EXACT instrument
时间窗: Daily recording
次要结局
- Medication usage and hospital admissions(Acutely)
- Changes in the St Georges Respiratory questionaire(Start and end of study period)
- Severity and duration of exacerbations assessed using the EXACT instrument(Daily recording)
