NCT04347928已完成不适用
Respiratory and Hemodynamic Changes Induced in Mechanically Ventilated Patients for COVID-19
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2020年4月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- intrapulmonary shunt ratio
研究概览
简要总结
In the present context, it seems necessary to try to describe as precisely as possible the physiological alterations due to COVID-19. From these observations, therapeutic proposals adapted to this new disease may then be developed, particularly in the symptomatic management of the critically ill patient. It therefore seems essential to rigorously study these modifications, as they have been studied in the past for ARDS.
The aim of this non-interventional study is to describe precisely the respiratory and hemodynamic changes induced by COVID-19 in mechanically ventilated patients
.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalized in intensive care for a SARS-CoV2 infection
- •requiring invasive ventilation,
- •intubated for less than 72 hours with PaO2/FiO2 ratio < 200 mmHg
排除标准
- •Patient mechanically ventilated for 72 hours or more
- •Patient with documented respiratory co-infection
- •Patient with a contraindication to pulmonary artery catheter insertion: High risk of bleeding, pre-existing high degree of atrioventricular heart block , Pace Maker
- •Patient with spontaneous ventilation
- •Patient with severe ARDS with static compliance of the respiratory system < 20 mL/cmH2O
- •Patient with severe ARDS with indication of prone positioning at inclusion.
- •Patient with a cardiac condition that renders the measurement of pulmonary artery occlusion pressure uninterpretable as a surrogate for left ventricle end diastolic pressure (severe mitral insufficiency, severe mitral stricture, severe aortic insufficiency).
- •Patient with intracardiac shunt
- •Patient with ECMO
- •Minors and pregnant women.
- •Person not affiliated to or not benefiting from a social security scheme.
结局指标
主要结局
intrapulmonary shunt ratio
时间窗: during ICU stay, in the first 72 hours of mechanical ventilation initiation
次要结局
- Evolution of respiratory variables(during ICU stay, in the first 72 hours of mechanical ventilation initiation)
- Evolution of hemodynamic stability variables(during ICU stay, in the first 72 hours of mechanical ventilation initiation)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Respiratory, hemodynamic and inflammatory effects of induced HypothermiA using NoVAtherm with extra corporeal membrane ventilator iLA-Activve in patients ARDSAcute respiratory distress syndromeNL-OMON26548Department of Intensive Care, Academic Medical Centre, University of Amsterdam30
已完成
不适用
An Examination of the Effect on Various Factors of Bed Baths Applied by Two Different Methods in Intensive Care PatientsPatient CareNCT05310825Uludag University22
已完成
不适用
Pulmonary Pathophysiology and Inflammatory Response in Patients Treated With Ecmo for Severe Respiratory FailureRespiratory Distress Syndrome, AdultRespiratory Distress Syndrome, ChildNCT01468142Karolinska University Hospital6
招募中
不适用
Comparison of hemodynamic and respiratory changes in anesthesia and laparoscopic gynecological surgeriesIRCT20180411039267N4Tabriz University of Medical Sciences74
Unknown
不适用
Gas Exchange and Cardiovascular Kinetics of Regulation - Effects of Short Term Changes in GravityHealthy VolunteersNCT02850354University Hospital, Caen18