The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 19
- 主要终点
- 24h ambulatory blood pressure
研究概览
简要总结
New data suggests that isometric handgrip training (IHT) might become a novel tool in the treatment of hypertension. The main purpose of this research project is to evaluate the effects of home-based IHT on ambulatory blood pressure in older adults with pre-hypertension and hypertension. Eighty-four older adults with pre-hypertension and hypertension will be randomly distributed to one of three groups: home-based IHT, home-based aerobic exercise training (AET), or attention-control group (CON). Each intervention will have a total duration of 8 weeks. At baseline and after completing the intervention, patients will undergo the following evaluations: 24-hour ambulatory blood pressure, cardiorespiratory fitness, endothelial function, damage and repair, arterial stiffness, inflammatory biomarkers, autonomic function, physical activity levels, dietary intake and quality of life. A qualitative analysis will also be applied to enhance the understanding of the efficacy of this intervention from the patient's perspective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Secondary Hypertension
- •Target Organ Damage
- •Coronary Artery Disease
- •Heart Failure
- •Any Previous Cardiovascular Event
- •Peripheral Artery Disease
- •Renal Failure
- •Chronic Obstructive Pulmonary Disease
- •Insulin Dependent Diabetes
- •Change of Antihypertensive Medication in the Past 4 Weeks Before Inclusion in the Study
- •Those Participating in Regular Physical Activity
研究组 & 干预措施
Aerobic Exercise Training
The 8-week exercise program will include three sessions of aerobic exercise per week
干预措施: Aerobic Exercise Training (Other)
Isometric Handgrip Training
The 8-week exercise program will include three sessions of isometric handgrip training per week
干预措施: Isometric Handgrip Training (Other)
Control Group
The control group will receive usual medical care
结局指标
主要结局
24h ambulatory blood pressure
时间窗: Change from baseline to 2 months
次要结局
- Arterial Stiffness(Change from baseline to 2 months)
- Inflamamtion(Change from baseline to 2 months)
- Health-related quality of life(Change from baseline to 2 months)
- Weekly physical activity sleep quality(Change from baseline to 2 months)
- Endothelial function(Change from baseline to 2 months)
- Endothelial cell repair/damage(Change from baseline to 2 months)
- Aerobic fitness(Change from baseline to 2 months)
- Intervention quality(two weeks after the intervention)
- Sleep quality(Change from baseline to 2 months)
研究者
Alberto Alves
Assistant Professor
University Institute of Maia