Can 5-HT3 receptor antagonists be used to limit vomiting in rota- and norovirus infections? - Can 5-HT3 receptor antagonists be used to limit vomiting in rota- and norovirus infections?

ennart Svensson Linköping University Medical Faculty0 个研究点开始时间: 2011年12月28日最近更新: 2015年8月17日

适应症

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•Inclusion criteria are: Children who have vomited (not blood, not bile and not feaces) at least once during the last four hours and had at least one non-bloody diarrhea during the illness period, and most have a mild to moderate dehydration should be included in the study.
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 215
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria are: severe dehydration or other disease that may obscure the assessment of dehydreringsgraden (renal failure or hypoabluminemi), formerly Ondansetron allergy, previous abdominal surgery, fructose intolerance, use of antiemetics during the last 72 hours, and previous participation in the study. Other exclusion criteria are severe congenital heart defects, immune deficiency, malignancy, malnutrition, cystic fibrosis, sickle cell anemia, diabetes mellitus and features suggestive of a disease other than gastroenteritis on medical examination (such as focal neurological signs or signs of increased intracranial pressure, acute abdominal surgical condition and supraventricular tachycardia).

发起方

ennart Svensson Linköping University Medical Faculty