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临床试验/NCT02901340
NCT02901340Unknown不适用

Third Trimester Fetal Renal Artery Doppler Indices in Borderline Idiopathic Isolated Oligohydramnios and Relationship Between Neonatal Outcomes

Kayseri Education and Research Hospital1 个研究点 分布在 1 个国家目标入组 140 人开始时间: 2016年8月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
140
试验地点
1
主要终点
Fetal renal artery pulsatile index in borderline idiopathic isolated oligohydramnios

研究概览

简要总结

The purpose of the study is to investigate third trimester fetal renal artery doppler indices in borderline idiopathic isolated oligohydramnios and relationship between neonatal outcomes.

详细描述

During a routine pregnancy examination at 34-37 weeks gestation, the fetus was evaluated using ultrasound with the Toshiba Xario 200 3.5-megahertz probe. Fetal biometric measurements were obtained and placental structure and the amniotic fluid amount were evaluated in four quadrants. After detailed ultrasonography of the fetus, eligible pregnant women were included in the study.

Borderline idiopathic isolated oligohydramnios was defined according to the four quadrants technical with ultrasound examination and diagnosed with amniotic fluid index >5.0 and ≤8.0cm. After first ultrasound examination all patients in borderline isolated oligohydramnios group were hydrated with one to two liters of water daily. All patients monitored with non stress test and amniotic fluid index twice weekly until delivery after treatment with hydration.

For evaluating renal artery blood flow, an axial image of the fetal abdomen was obtained at the level of the fetal kidneys. Using color flow Doppler, the renal arteries were evaluated at the level of their origin from the abdominal aorta. The Doppler gate was placed within the lumen in a straight segment of the vessel. A minimum of three consecutive waveforms was used to calculate the PI. The umbilical artery Doppler measurements were studied in a free loop of cord, far from the fetus and placenta. pulsatile index and resistance index values were recorded.

The study consisted of two groups. The first group was formed of the patients who had normal amniotic volume and meets the inclusion criteria. In second group the investigators included patients who diagnosed borderline idiopathic isolated oligohydramnios. After delivery the investigators compared fetal renal artery doppler indices and neonatal outcomes between groups.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • singleton pregnancies
  • between 34-37 gestational weeks
  • the age of them ranged from 18 to 35 years

排除标准

  • uteroplacental insufficiency
  • preeclampsia
  • chronic hypertension
  • collagen vascular disease
  • nephropathy
  • chromosomal abnormalities
  • congenital abnormalities, especially those associated with impaired urine production
  • growth restriction
  • ruptured fetal membranes
  • twin pregnancies

结局指标

主要结局

Fetal renal artery pulsatile index in borderline idiopathic isolated oligohydramnios

时间窗: 4 months

次要结局

未报告次要终点

研究者

发起方
Kayseri Education and Research Hospital
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Erdem Sahin

Principal Investigator

Kayseri Education and Research Hospital

研究点 (1)

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