Intervention Focused on Lower Limbs and Functionality in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Changes in manual dexterity
研究概览
简要总结
Multiple sclerosis is a chronic and highly disabling disorder with considerable social impact and economic consequences. It is caused by damage to the myelin sheath, the protective covering that surrounds nerve cells. Different areas are affected, including manual dexterity, strength, coordination and function. The objective of this study is to evaluate the improvement in these variables in patients with multiple sclerosis after a 8-weeks intervention focused on upper limbs.
详细描述
The total estimated prevalence rate of multiple sclerosis has been reported to be 83 per 100 000 for the past three decades. It is also higher in northern countries and between females with a male ratio around 2.0. The highest prevalence rates have been estimated for the age group 35-64 years. The estimated European mean annual Multiple Sclerosis incidence rate is 4.3 cases per 100 000.
Multiple sclerosis can cause a variety of symptoms: hypoesthesia, muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; dysarthria, dysphagia, visual problems fatigue and acute or chronic pain syndromes, bladder and bowel difficulties,cognitive impairment, or emotional symptomatology. The investigators focus on the benefits of an intervention on dexterity, strength, coordination and functionality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with multiple sclerosis.
- •Subjects who can complete the assessment battery of tests at the beginning and at the end of the study
排除标准
- •Auditive and visual disturbances.
- •Cognitive problems.
- •Psychiatric pathology.
- •Sensorial disturbances.
- •Traumatic pathology of the hand.
- •Concomitant neurological conditions
结局指标
主要结局
Changes in manual dexterity
时间窗: baseline, 8 weeks
Changes from baseline to postintervention in manual dexterity assessed by the Purdue Pegboard test and coin rotation task. The Purdue pegboard test is a timed physical test used to measure manual dexterity. Test subjects are asked to place small pins into holes in the pegboard using a specific hand and following a specific process. The coin rotation task consists of rotate the coin during 10 seconds.
次要结局
- Upper limb functioning(baseline, 8 weeks)
- Changes in apraxia(baseline, 8 weeks)
- Changes in grip strength(baseline, 8 weeks)
- Change in fatigue(baseline, 8 weeks)
- Tapping speed(baseline, 8 weeks)
- Pinch strength(baseline, 8 weeks)
研究者
Marie Carmen Valenza
assistant professor
Universidad de Granada